Table 1.

PICOTS criteria for study inclusion

	Inclusion criteria
Population	At least 10 patients with newly diagnosed OPSCC (including oropharyngeal sublocations such as tonsil) and treated at a German medical center
Intervention	HPV status determined by HPV DNA PCR combined with p16INK4a immunohistochemistry on pretreatment tumor biopsies
Comparisons	None
Outcome	HPV‐attributable fraction (prevalence of HPV DNA PCR and p16INK4a positive OPSCC)
Time	All eligible studies will be included regardless of publication time or study duration, if they were retrievable by the searched databases by January 10, 2018
Study design	Prospective and retrospective studies including patients with newly diagnosed OPSCC without evident selection for eg stage or histology
Other	None