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. 2019 Apr 11;43(6):2440–2450. doi: 10.3892/ijmm.2019.4163

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Copyright: © Gu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of TXNIP gene silencing on NLRP3 inflammasome activation-associated proteins and inflammation-associated factors. (A) Western blots and (B) quantified expression levels of TXNIP, NLRP3, cleaved-caspase-1 and caspase-1 proteins in the control, HG, NC + HG, siTXNIP and siTXNIP + HG groups. (C) IL-1 and (D) IL-18 expression levels in each group were detected by ELISA. ^*P<0.05 and ^**P<0.01, vs. control group; ^#P<0.05 and ^##P<0.01. TXNIP, thioredoxin interacting protein; NLRP3, NOD-like receptor protein 3; IL, interleukin; HG, high glucose; NC, negative control siRNA; si-, small interfering RNA.