Table II.

Changes in BUN and SCr in rat DN model.

Time	Parameter	Control	DN	P-value
1 week	BUN (mmol/l)	7.83±0.73	14.96±0.94	<0.001
	SCr (µmol/l)	37.44±1.15	46.85±1.42	<0.001
2 weeks	BUN (mmol/l)	8.04±0.79	18.56±1.67	<0.001
	SCr (µmol/l)	38.17±1.72	55.79±1.78	<0.001
3 weeks	BUN (mmol/l)	8.21±0.81	21.83±1.59	<0.001
	SCr (µmol/l)	39.08±2.73	62.85±1.94	<0.001

DN, diabetic nephropathy; BUN, blood urea nitrogen; SCr, serum creatinine.