Table 4. Hyperinsulinemic euglycemic clamp values.

	WT	KO
Basal blood glucose, mmol/L	6.26 ±0.14	5.97 ±0.22
Clamp blood glucose, mmol/L	6.75 ±0.21*	5.78 ±0.14
Basal plasma insulin, μU/mL	19.59 ±6.47	7.92 ±1.12
Clamp plasma insulin, μU/mL	498.01 ±3.58	500.95 ±12.22
GIR, μmol/kg/min	219.62 ±10.98†	101.95 ±7.13
Clamp GTR, μmol/kg/min	233.49 ±17.88†	112.16 ±7.86
Basal HGP, μmol/kg/min	44.12 ±3.36	45.67 ±3.81
Clamp HGP, μmol/kg/min	13.88 ±9.29	10.20 ±5.30
Suppression of HGP rate, %	71.49 ±20.19	80.43 ±11.50

Values means ± SEM (n = 5–6 rats per genotype). WT, wildtype. KO, AS160-KO. GIR, glucose infusion rate. GTR, glucose turnover rate. HGP, hepatic glucose production.

*P < 0.05

^†P <0.001, WT versus KO.