Table 4.
Differences in polymorphisms of various CagLHM sequence types of 46 H pylori isolates in relation to virulence genotypes and cagPAI integrity
| Virulence genotypes | CagLHM sequence type polymorphism | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
NEIGQ (n = 21) |
NKIGQ (n = 9) |
DKIGQ (n = 4) |
NKMGQ (n = 3) |
NKMGK (n = 3) |
NKISQ (n = 2) |
NEIGK (n = 1) |
DKMGE (n = 1) |
DEIGQ (n = 1) |
DKMGQ (n = 1) |
Total (n = 46) |
|
| vacA s1m1 | 5 | 4 | 1 | 1 | 1 | — | — | — | 1 | 1 | 14 |
| vacA s1m2 | 12 | 2 | 3 | 1 | 2 | 1 | 1 | — | — | — | 22 |
| vacA s2m2 | 4 | 3 | — | 1 | — | 1 | — | 1 | — | — | 10 |
| babA2+ | 20 | 9 | 4 | 3 | 3 | 1 | 1 | 1 | 1 | 1 | 44 |
| babA2− | 1 | — | — | — | — | 1 | — | — | — | — | 2 |
| sabA+ | 16 | 7 | 3 | 3 | 3 | 2 | 1 | 1 | 1 | 1 | 38 |
| sabA− | 5 | 2 | 1 | — | — | — | — | — | — | — | 8 |
| EPIYA motifs | |||||||||||
| ABC | 14 | 7 | 3 | 2 | 3 | 2 | 1 | 1 | 1 | 1 | 35 |
| ABCC | 4 | 1 | 1 | — | — | — | — | — | — | — | 6 |
| ABCCC | 1 | — | — | — | — | — | — | — | — | — | 1 |
| Mixed typea | 1 | — | — | 1 | — | — | — | — | — | — | 2 |
| cagA− | 1 | 1 | — | — | — | — | — | — | — | — | 2 |
| cagPAI integrity | |||||||||||
| Intact cagPAI | 14 | 6 | 4 | 2 | 3 | 1 | — | 1 | 1 | 1 | 33 |
| Partial cagPAI | 7 | 3 | — | 1 | — | 1 | 1 | — | — | — | 13 |
CagLHM, CagL hypervariable motif; GC, gastric cancer; GE, gastric erosion; NUD, non‐ulcer dyspepsia; PUD peptic ulcer disease.
The “—” denotes none detected.
a
Denotes multiple cagA EPIYA motifs of different sizes, indicating mixed infections.