Table 3.

Associations of MATLA1 expression with breast cancer survival stratified by tumor grade and/or hormone receptor status

MALAT1	RFS		P value	OS		P value	RFS*		P value	OS*		P value
	HR	95% CI		HR	95% CI		HR	95% CI		HR	95% CI
Grade 1or 2
Low	1			1			1			1
Mid	4.17	1.53-11.35	0.0052	2.36	0.95-5.87	0.064	3.88	1.39-10.88	0.0099	3.46	1.20-0.02	0.022
High	3.45	1.26-9.45	0.016	1.56	0.61-4.03	0.36	2.64	1.26-9.76	0.016	2.41	0.83-7.03	0.11
Continuous	1.58	1.06-2.37	0.024	1.19	0.79-1.81	0.41	1.63	1.07-2.47	0.023	1.41	0.89-2.21	0.14
Grade 3
Low	1			1			1			1
Mid	1.32	0.63-2.74	0.46	1.04	0.47-2.31	0.93	1.33	0.61-2.88	0.47	0.97	0.40-2.31	0.94
High	2.15	1.11-4.16	0.023	1.47	0.71-3.05	0.30	2.57	126-5.23	0.0094	2.02	0.91-4.49	0.085
Continuous	1.49	1.07-2.07	0.019	1.22	0.84-1.77	0.29	1.64	1.15-2.34	0.0067	1.46	0.96-2.21	0.075
ER+ or PR+
Low	1			1			1			1
Mid	2.18	1.09-4.36	0.027	1.30	0.65-2.57	0.46	2.32	1.13-4.75	0.022	2.74	1.04-7.21	0.041
High	2.43	1.23-4.78	0.011	1.26	0.64-2.48	0.51	2.82	1.39-5.73	0.0042	2.46	0.97-6.28	0.059
Continuous	1.49	1.09-2.02	0.012	1.12	0.80-1.55	0.52	1.61	1.16-2.22	0.0042	1.45	0.96-2.18	0.075
ER− and PR−
Low	1			1			1			1
Mid	1.77	0.69-4.57	0.24	1.45	0.50-4.17	0.22	1.59	0.61-4.19	0.35	1.06	0.34-3.27	0.92
High	1.86	0.72-4.79	0.20	1.70	0.60-4.77	0.51	1.81	0.64-5.12	0.26	1.30	0.39-4.29	0.67
Continuous	1.34	0.85-2.09	0.21	1.29	0.78-2.14	0.32	1.34	0.81-2.22	0.26	1.14	0.63-2.09	0.66
Grade 1or 2 and ER+ or PR+
Low	1			1			1			1
Mid	3.55	1.28-9.81	0.015	2.30	0.86-6.15	0.096	3.50	1.21-10.16	0.021	4.09	1.24-13.44	0.020
High	2.92	1.05-8.15	0.041	1.78	0.66-4.82	0.26	3.13	1.08-9.04	0.035	3.20	0.99-10.36	0.053
Continuous	1.50	0.99-2.29	0.058	1.26	0.81-1.97	0.30	1.58	1.01-2.48	0.046	1.56	0.95-2.57	0.078

^*Adjusted for age at surgery and disease stage, as well as tumor grade or ER/PR status when they were not used for stratification.