Figure 5. Clonal dynamics promoted by somatic driver mutations in early developing HSC pools.

(A) The MMC model demonstrates an uninterrupted increase in mutant clone frequencies over time. Other parameters as listed in Standard parameter set MMC, Standard parameter sets, Supplementary Materials. (B). The MMC-DS model demonstrates early peak frequencies of mutant clones which are later suppressed by purifying selection acting throughout the early half of the simulated lifespan. Other parameters as listed in Standard parameter set MMC-DS, Standard parameter sets, Supplementary Materials.