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. 2019 Apr 15;8:e42265. doi: 10.7554/eLife.42265

Figure 4. PPI and DCM results of the first fMRI sample.

(a) Regions showing positive (red) and negative (blue) associations with AIC activation modulated by interoceptive attention relative to exteroceptive attention (BDT vs. DDT). (b) An increase in activation in the right AIC was associated with an increase in activation in the postcentral gyrus (PoCG) and a decrease in activation in the visual cortex (VC, V2/3) under the condition of interoceptive attention compared with exteroceptive attention. (c) Five base models generated by specifying possible modulations of interoceptive and exteroceptive attention (BDT and DDT) on the four endogenous connections between ROIs. The model surrounded by a rectangle in dashed-line indicates the winning model out of 52 variant models revealed by random-effects Bayesian model selection (BMS). (d) Intrinsic efferent connection from the AIC to the PoCG was significant. The modulatory effect of interoceptive attention (BDT) on the connection from the AIC to the PoCG was significant. The modulatory effect of exteroceptive attention (DDT) on the connection from AIC to V2/3 was significant (uncorrected).

Figure 4—source data 1. CSV file containing data for Figure 4b.
elife-42265-fig4-data1.csv (76.8KB, csv)
DOI: 10.7554/eLife.42265.021

Figure 4.

Figure 4—figure supplement 1. Regions showed positive (red) and negative (blue) association with the left AIC (as the seed) modulated by interoceptive attention relative to exteroceptive attention (BDT vs DDT) for the first fMRI sample.

Figure 4—figure supplement 1.

Figure 4—figure supplement 2. Exceedance probability of RFX BMS for the first fMRI sample.

Figure 4—figure supplement 2.

Across all 52 models, M20 outperformed the other models and thus was identified as the optimal model. M20 denotes the model with the modulatory effects of interoceptive and exteroceptive attention (BDT and DDT) exerting on the connection from the AIC to the PoCG and to the V2/3.