Figure 1. Sting^gt/gt mice are susceptible to tumors independently of effects on T and B cells.

Tumor cells were injected s.c. into mice (n=4-6). Tumor growth was assessed by caliper measurements, and statistical significance was assessed by 2-way ANOVA. Bars represent +/− means SEM. Results are representative of two to four independent experiments. Tumors were injected into WT or Sting^gt/gt mice (A, C), into WT or Irf3^−/− mice (B, D), or into Rag2^−/− or Rag2^−/− Sting^gt/gt mice (E,F,G). The mice were injected with the following tumor doses: (A, B, E) 2 × 10⁵ RMA-S or RMA cells; (C, D, F) 2 × 10⁴ B16-BL6 cells; (F) 5 × 10⁴ RMA-RAE-1ε cells; (G) 10⁵ MC38 cells