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. Author manuscript; available in PMC: 2020 May 20.
Published in final edited form as: Free Radic Biol Med. 2019 Mar 26;136:12–21. doi: 10.1016/j.freeradbiomed.2019.03.026

Figure 7. ATM and DNA-PK in cellular resistance to BLM.

Figure 7.

(A) Soluble and chromatin-bound fractions of autophosphorylated ATM in H460 cells (1 h BLM treatments). (B) Activating DNA-PK autophosphorylation in control and DHA-preincubated H460 and A549 cells treated with BLM for 1 h. (C) Clonogenic survival of A549 cells treated with BLM in the presence of inhibitors of ATM (1 μM KU60019) and DNA-PK (3 μM NU7441). Inhibitors were present during BLM treatments and for the next three days of growth. Means±SD, n=3, *- p<0.05, **-p<0.01, ***-p<0.001.