Table 1.
Demographics and baseline testing
| PIB Negative |
PIB Positive |
p | Total |
||||
|---|---|---|---|---|---|---|---|
| N/Mean | %/SD | N/Mean | %/SD | N/Mean | %/SD | ||
| Age, y | 71.9 | 3.1 | 74.5 | 4.3 | 0.139 | 73.2 | 3.9 |
| Women, N | 5 | 50.0% | 2 | 20.0% | 0.160 | 7 | 35.0% |
| APOE ɛ4, N | 3 | 30.0% | 4 | 40.0% | 0.639 | 7 | 35.0% |
| Education, y | 16.6 | 1.7 | 16.0 | 2.8 | 0.565 | 16.3 | 2.3 |
| MCBP for PIB | 0.03 | 0.03 | 0.46 | 0.26 | <0.001 | 0.25 | 0.28 |
| CSF Aβ42, pg/mL | 840.4 | 221.8 | 524.5 | 206.6 | 0.004 | 682.5 | 264.2 |
| tau, pg/mL | 227.9 | 64.3 | 523.5 | 285.1 | 0.001 | 375.7 | 251.9 |
| ptau181, pg/mL | 45.2 | 8.5 | 85.7 | 36.4 | 0.007 | 65.5 | 33.1 |
| Selective Reminding Test - Free Recall | 34.6 | 5.1 | 28.1 | 7.2 | 0.031 | 31.4 | 6.9 |
| Animal Naming | 23.0 | 5.8 | 19.6 | 4.6 | 0.166 | 21.3 | 5.4 |
| Trailmaking A, s | 27.7 | 7.4 | 32.7 | 10.7 | 0.240 | 30.2 | 9.3 |
| Trailmaking B, s | 79.4 | 39.8 | 92.1 | 41.1 | 0.516 | 85.8 | 39.8 |
| Santa Barbara Sense of Direction | 5.8 | 1.0 | 4.7 | 1.2 | 0.052 | 5.2 | 1.2 |
| Near acuity | 68.0 | 1.8 | 65.5 | 3.9 | 0.083 | 66.8 | 3.2 |
| Far acuity | 48.6 | 7.3 | 48.4 | 43.6 | 0.950 | 48.5 | 6.8 |
| Contrast sensitivity | 21.8 | 8.5 | 21.0 | 8.4 | 0.834 | 21.4 | 8.2 |
PIB, Pittsburgh Compound B; SD, standard deviation; MCBP, mean cortical binding potential; s, seconds.