. Author manuscript; available in PMC: 2020 May 1.

Published in final edited form as: Brain Behav Immun. 2019 Jan 11;78:21–30. doi: 10.1016/j.bbi.2019.01.002

Table 4.

Moderation of the Association Between Average Sleep Duration and Markers of Inflammation by rs6198 Genotype

	IL-6						CRP
	Model 1		Model 2		Model 3		Model 4		Model 5
Variables	β	p	β	p	β	p	β	p	β	p

Age	.053	.126	.051	.138	.048	.162	−.022	.533	−.022	.535
Sex	−.098	.005	−.099	.004	−.097	.005	.011	.757	.010	.763
Education	−.095	.006	−.095	.006	−.095	.006	−.072	.037	−.072	.036
Avg Sleep	−.092	.009	−.190	.001	−.080	.023	−.052	.150	−.083	.162
rs6198	.056	.104	.057	.094			.026	.448	.034	.414
rs6198 GG					.068	.047
rs6198*Avg Sleep			−.123	.033					−.039	.508
rs6198 GG*Avg Sleep					−.074	.033
(Avg Sleep)²							.085	.016	.064	.401
rs6198*(Avg Sleep)²									−.016	.745

F	6.14	< .001	5.91	< .001	6.06	< .001	2.69	.014	2.07	.036
R²	.036		.041		.042		.019		.019
ΔR²			.005	.033	.005	.033			.001	.791

Notes: Age & Education in years; Sex: 0 = male, 1 = female; Avg Sleep = weighted average of weeknight and weekend sleep duration (hours); Avg sleep is mean centered in all models; rs6198: a glucocorticoid receptor SNP with an A to G substitution. ‘rs6198’ is coded as 1 (GG), 0 (AG), and −1 (AA). ‘rs6198 GG’ is coded 0 (AG/AA), 1 (GG).