Skip to main content
. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Psychoneuroendocrinology. 2019 Mar 12;104:219–227. doi: 10.1016/j.psyneuen.2019.03.007

Figure 1.

Pre-scan cortisol is associated with relative hyper-connectivity of DMN and SN seed regions in rMDD compared to HC

Figure 1.

*interactive Effects of Cortisol: Blue = Cortisol positively related to foci of connectivity from bilateral PCC seeds in rMDD but not HC; Cyan = Cortisol positively related to foci of connectivity from bilateral antHPF seeds in rMDD but not HC; Red = Cortisol positively related to foci of connectivity from bilateral sgACC seeds in rMDD but not HC; Violet = Cortisol positively related to foci of connectivity from bilateral amygdala seeds in rMDD but not HC. *In a multivariate analysis of covariance using extracted data for each cluster as dependent variables, all diagnosis x cortisol interactions remained significant after adjusting for BMI, F(19, 84) = 2.52,

p = .013. Additionally, there were no significant main effects of BMI in relation to brain clusters reported for diagnosis x cortisol interactions F(19, 84) = .77, p = .79, nor were there any significant diagnosis x cortisol x BMI interactions F(16, 84) = .79, p = .83.