Table 4.
Foci of connectivity in pre-scan cortisol regression from bilateral amygdala seed
| Left Amygdala Seed | Right Amygdala Seed | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MNI coordinates | MNI coordinates | |||||||||||
| Contrast/Lobe | BA | x | y | z | Z | k | BA | x | y | z | Z | k |
| Cortisol by Diagnosis Interaction | ||||||||||||
| Positive Association in rMDD | ||||||||||||
| Frontal | ||||||||||||
| Superior Frontal | 10 | −28 | 54 | 14 | 4.29 | 318 | 9/10 | 14 | 62 | 26 | 3.39 | 489 |
| Precentral | -- | -- | -- | -- | -- | -- | 9/10 | −42 | 8 | 42 | 4.45 | 356 |
| -- | -- | -- | -- | -- | -- | 9/10 | −50 | 24 | 26 | 3.37 | 103^ | |
| Middle Frontal | 10 | −38 | 58 | −8 | 3.74 | 108 | 10 | −34 | 48 | 14 | 4.61 | 507 |
| 10 | 38 | 54 | 12 | 3.86 | 958 | 9/10 | 44 | 24 | 38 | 3.33 | 140 | |
| Medial Frontal | -- | -- | -- | -- | -- | -- | 8 | −6 | 32 | 48 | 4.40 | 1254 |
| Inferior | -- | -- | -- | -- | -- | -- | 47 | 44 | 18 | −16 | 3.91 | 230 |
| Parietal | ||||||||||||
| Inferior Parietal Lobule | 40 | 60 | −28 | 34 | 3.65 | 195^ | -- | -- | -- | -- | -- | -- |
| Precuneus | -- | -- | -- | -- | -- | -- | 7 | 14 | −52 | 58 | 3.54 | 167 |
| Temporal | ||||||||||||
| Parahippocampal Gyrus | 30 | 28 | −46 | −12 | 3.42 | 181 | 30/36 | −48 | 34 | −14 | 4.98 | 1732 |
| Inferior Temporal | -- | -- | -- | -- | -- | -- | 20 | −56 | −8 | −28 | 3.64 | 176 |
| Uncus | 36 | −28 | −8 | −40 | 3.60 | 111 | -- | -- | -- | -- | -- | -- |
| Occipital | ||||||||||||
| Precuneus | 11 | −12 | −66 | −26 | 3.15 | 138 | -- | -- | -- | -- | -- | -- |
| Cuneus | 17/18/19 | 6 | −78 | 46 | 4.33 | 661 | 17 | −10 | −82 | −18 | 3.39 | 164 |
| Subcortical | ||||||||||||
| Thalamus, Lateral Posterior | 22 | −18 | 22 | 3.99 | 222 | −16 | −20 | 20 | 3.52 | 150 | ||
| Nucleus/Pulvinar | ||||||||||||
| Caudate | -- | -- | -- | -- | -- | −12 | 10 | 10 | 3.75 | 297 | ||
| Cerebellum, Declive | 0 | −80 | −10 | 3.23 | 272 | -- | -- | -- | -- | -- | ||
| 20 | −76 | −12 | 3.52 | 142^ | -- | -- | -- | -- | -- | |||
| Cerebellum, Tuber | −44 | −82 | −28 | 4.00 | 100 | -- | -- | -- | -- | -- | ||
| Cerebellum, Pyramis | -- | -- | -- | -- | -- | 22 | −78 | −34 | 3.88 | 443 | ||
| Cerebellum, Inferior Semi Lunar Lobule | −26 | −82 | −38 | 4.01 | 305 | |||||||
^
Attenuated to trend effects and no longer reached the statistically significant threshold in sensitivity analyses excluding UM participants