Table 5.
Foci of connectivity in pre-scan cortisol regression from bilateral subgenual anterior cingulate cortex seed
| Left SgACC Seed | Right SgACC Seed | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MNI coordinates | MNI coordinates | |||||||||||
| Contrast/Lobe | BA | x | y | z | Z | k | BA | x | y | z | Z | k |
| Cortisol by Diagnosis Interaction | ||||||||||||
| Positive Association in rMDD | ||||||||||||
| Frontal | ||||||||||||
| Anterior Cingulate | 32 | −12 | 26 | 42 | 3.61 | 495 | -- | -- | -- | -- | -- | -- |
| Middle Frontal | 6/8/9 | −42 | 20 | 24 | 3.97 | 631 | 6/8/9 | −4 | 34 | 40 | 3.90 | 300^ |
| Inferior Frontal | 47 | −42 | 28 | −6 | 3.60 | 478 | 47 | −44 | 24 | −4 | 3.66 | 334 |
| 45 | −38 | 34 | 6 | 3.50 | 119 | |||||||
| Parietal | ||||||||||||
| Precuneus | 7 | −26 | −74 | 58 | 3.42 | 569 | -- | -- | -- | -- | -- | -- |
| Temporal | ||||||||||||
| Superior Temporal | 38 | 38 | 14 | −36 | 3.66 | 172 | 39 | −56 | −56 | 26 | 3.47 | 150^ |
| Fusiform Gyrus | -- | -- | -- | -- | -- | -- | 37 | 54 | −60 | −8 | 3.66 | 121 |
| Uncus | 34 | −20 | 0 | −22 | 3.51 | 114 | -- | -- | -- | -- | -- | -- |
| Occipital | ||||||||||||
| Middle Occipital | 19 | −58 | −62 | 0 | 3.44 | 277^ | 19 | −58 | −62 | −2 | 3.55 | 218 |
| 19 | 36 | −90 | 10 | 3.40 | 175 | -- | -- | -- | -- | -- | -- | |
| Precuneus | -- | -- | -- | -- | -- | -- | 31 | −30 | −74 | 24 | 3.58 | 181 |
| -- | -- | -- | -- | -- | -- | 31 | 54 | −60 | −32 | 3.71 | 203^ | |
| Subcortical | ||||||||||||
| Anterior Insula | 13 | −46 | 14 | 16 | 3.72 | 319^ | ||||||
| Cerebellum, Tuber | −44 | −74 | −26 | 4.01 | 476 | -- | -- | -- | -- | -- | ||
| Cerebellum, Pyramis | -- | -- | -- | -- | -- | -- | −16 | −82 | −30 | 4.25 | 1055 | |
| Cerebellum, Inferior Semi Lunar Lobule | -- | -- | -- | -- | -- | -- | 12 | −78 | −36 | 3.80 | 302 | |
^
Attenuated to trend effects and no longer reached the statistically significant threshold in sensitivity analyses excluding UM participants