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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Eur J Med Chem. 2019 Apr 5;173:32–43. doi: 10.1016/j.ejmech.2019.03.065

Scheme 2.

Scheme 2.

Reagents and conditions: (a) DCM, TEA, ice bath to r.t., 8 h, 50%; (b) CH3CN, K2CO3, reflux, 4 h, 80–91%; (c) i. DCM, TFA, r.t., 8 h; ii. NaHCO3, 87–90%; (d) DCM, TEA, HOBT, EDCI, r.t., 16 h, 77-84%.