Table 2.
Demographic and Baseline Clinical Variables
| Characteristic | Bilateral (n=20) | Unilateral (n=11) |
Sham (n=12) |
|---|---|---|---|
| Age, y, mean (SD) | 66.8 (5.8) | 66.1 (8.5) | 64.1 (3.7) |
| Gender, M/F | 13/7 | 4/7 | 3/9 |
| Years of education, mean (SD) | 14.5 (3.2) | 12.6 (2.7) | 16.9 (4.1) |
| Onset age, y, mean (SD) | 32.1 (16.7) | 20.1 (14.7) | 38.5 (14.7) |
| Duration of current episode, months, mean (SD) | 27.2 (16.3) | 17.7 (10.1) | 31.4 (28.1) |
| Number of episodes, mean (SD) | 2.9 (2.7) | 3.3 (3.2) | 3.9 (4) |
| Current episode severe (%) | 2 (10) | 4 (36.4) | 1 (8.3) |
| Current episode moderate (%) | 18 (90) | 7 (63.6) | 11 (91.7) |
| Atypical features (%) | 2 (10) | 2 (18.2) | 1 (8.3) |
| Melancholic features (%) | 3 (15) | 0 (0) | 0 (0) |
| Prior Medication History | |||
| SSRI (%) | 10 (50) | 5 (45.5) | 7 (58.3) |
| SNRI (%) | 6 (30) | 4 (36.4) | 5 (41.7) |
| TCA (%) | 7 (35) | 6 (54.5) | 8 (66.7) |
| Mirtazapine (%) | 4 (20) | 1 (9.1) | 1 (8.3) |
| Lithium (%) | 1 (5) | 0 (0) | 0 (0) |
| Active Medication During Study | |||
| Benzodiazepine (%) | 6 (30) | 4 (36.4) | 5 (41.7) |
| Antipsychotic (%) | 4 (20) | 3 (27.3) | 2 (16.7) |
| No antidepressant (%) | 3 (15) | 0 (0) | 0 (0) |
| ATHF score, mean (SD) | 6.8 (4.0) | 5.7 (2.2) | 4.6 (2.1) |
| Baseline HDRS, mean (SD) | 24.6 (4.2) | 26.5 (3.4) | 24.5 (3.5) |
SD = standard deviation; y = years; M/F = male/female; SSRI = selective serotonin reuptake inhibitor; SNRI = serotonin-norepinephrine reuptake inhibitor; TCA = tricyclic antidepressant; ATHF = antidepressant treatment history form; HDRS = 17-item Hamilton Depression Rating Scale.