. Author manuscript; available in PMC: 2020 May 1.

Published in final edited form as: Brain Behav Immun. 2019 Jan 12;78:9–20. doi: 10.1016/j.bbi.2019.01.004

Table 1.

Role of CREB in PBMC.

Cell Type	Role of CREB
T cells	• Proliferation and survival. •Production of IL-2, IFN-γ, and IL-4 by CD4+ T cells. •Regulation of Th17 and Treg differentiation via TGFβ and IL-6. •Production of IL-17 by Th17 cells.
B cells	• Proliferation and survival.
NK cells	• Mediates response to IL-2.
Macrophages	• Production of IL-10.
Dendritic cells	•Maturation. •Production of IL-10.