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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Adv Biol Regul. 2018 Dec 13;72:89–101. doi: 10.1016/j.jbior.2018.12.001

Figure 2. Synthesis of O-acylceramide by an ACSL-CerS-DGAT2 enzymatic complex.

Figure 2.

Synthesis of O-acylceramide from ceramide is carried out by the enzymatic complex ACSL-CerS-DGAT2 localized to the ER/lipid droplet contact sites. Fatty acyl-CoA synthase (ACSL) catalyzes the synthesis of the activated fatty acid (FA) as fatty acyl-CoA (FA-CoA). Ceramide synthase (CerS) synthesize ceramide by N-acylating the sphingosine backbone. Acyl-CoA:diacylglycerol acyltransferase (DGAT2) transforms ceramide to O-acylceramide by transferring a FA group from FA-CoA to the hydroxyl group likely in the carbon-1 of ceramide.