Skip to main content
. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Hepatology. 2019 Feb 19;70(2):696–710. doi: 10.1002/hep.30334

FIG. 6.

FIG. 6

DAP12 and TREM2 regulate the severity of mouse liver IRI. Injury was induced in sham-operated B6 WT, DAP12−/− or TREM2−/− mice by 70% clamping, as described in the Materials and Methods. IRI was determined 6 hours after clamp release. (A) Serum ALT levels in 5-8 mice per group. Data shown are means + SEM. (B) H&E staining of injured liver tissue. (C) Areas of necrosis were quantified by Image J. Data shown are means + SEM obtained from n = 3 animals in each group. (D)Serum IL-6 and TNFα levels evaluated 6 hours after clamp release. Data are means ± SEM obtained from n = 5-8 mice per group. (E) Cell surface costimulatory molecule (CD86) expression by liver and spleen DC 6 hours after liver IR. Data are means + SEM obtained from n = 3 mice in each group. *p<0.05; **p<0.01; ***p<0.001.