Fig. 4.

Concentration-time profiles of observed data and model predictions in one individual (p40) for the [¹¹C]erlotinib + rifampicin data set. Concentration-time profiles in the liver and extrahepatic bile duct/gall bladder in the baseline scan (a, b) and in the scan acquired after i.v. administration of rifampicin (c, d). Observed data is represented with open black circles; modeled data is represented with colored lines (AIF, arterial input function; DIF, dual input function; 3C, three compartment; 4C, four compartment)