Table I.
Parameter Estimates of the 3C Model for the [11C]Erlotinib + Erlotinib Data Set
| Subject | Arterial input functiona | Dual input functionb | |||||
|---|---|---|---|---|---|---|---|
| k1 (min−1) | k2 (min−1) | k3 (min−1) | k1 (min−1) | k2 (min−1) | k3 (min−1) | β (min) | |
| Baseline scan | |||||||
| p12 | 1.700 (2) | 0.001 (28) | 0.004 (1) | 4.207 (2) | 0.0001 (71) | 0.007 (1) | 0.899 (152) |
| p13 | 1.989 (4) | 0.032 (5) | 0.003 (2) | 4.501 (7) | 0.033 (7) | 0.004 (2) | 0.812 (272) |
| p14 | 1.599 (2) | 0.012 (4) | 0.005 (1) | 4.178 (3) | 0.011 (10) | 0.010 (1) | 0.801 (42) |
| p15 | 2.212 (2) | 0.010 (5) | 0.006 (1) | 4.683 (4) | 0.003 (13) | 0.006 (1) | 1.720 (57) |
| p24 | 1.888 (3) | 0.018 (4) | 0.002 (1) | 4.553 (5) | 0.017 (4) | 0.004 (1) | 1.753 (74) |
| p30 | 1.238 (2) | 0.010 (4) | 0.006 (1) | 3.124 (3) | 0.006 (6) | 0.010 (1) | 1.714 (22) |
| Mean ± SD | 1.771 ± 0.339 | 0.016 ± 0.009 | 0.004 ± 0.002 | 4.208 ± 0.567 | 0.012 ± 0.012 | 0.007 ± 0.003 | 1.283 ± 0.490 |
| Second scan (after oral erlotinib) | |||||||
| p12 | 2.201 (7) | 0.119 (7) | 0.004 (2) | 3.891 (7) | 0.070 (6) | 0.005 (2) | 0.805 (81) |
| p13 | 2.299 (14) | 0.150 (14) | 0.001 (3) | 3.349 (15) | 0.103 (15) | 0.002 (3) | 1.649 (58) |
| p14 | 1.978 (6) | 0.156 (6) | 0.004 (1) | 3.499 (4) | 0.100 (4) | 0.006 (1) | 0.799 (52) |
| p15 | 2.810 (11) | 0.201 (10) | 0.003 (2) | 3.394 (6) | 0.094 (6) | 0.005 (2) | 0.899 (47) |
| p24 | 2.600 (11) | 0.188 (10) | 0.001 (3) | 5.110 (10) | 0.180 (9) | 0.001 (3) | 1.558 (49) |
| p30 | 2.080 (11) | 0.137 (10) | 0.0001 (3) | 3.585 (7) | 0.092 (6) | 0.0002 (2) | 2.154 (53) |
| Mean ± SD | 2.328 ± 0.319 | 0.159 ± 0.031 | 0.002 ± 0.002 | 3.805 ± 0.668 | 0.107 ± 0.038 | 0.003 ± 0.002 | 1.311 ± 0.561 |
Values in parentheses represent percent coefficient of variation (%CV) of the parameter (parameter precision), calculated as (SE(pi)/pi)100, where pi is the parameter estimate and SE is the asymptotic standard error of the mean of pi. k1 and k2 are the exchange rate constants between blood and liver tissue, and k3 is the rate constant describing transfer from the liver to the extrahepatic bile duct and gall bladder. β is the mean transit time for the passage of radiotracer from intestinal arteries to the portal vein
a3C model using the blood sampled from the radial artery as the model input function. β estimation is not necessary since portal vein concentration is not calculated
b3C model using the dual input (combination of hepatic artery and portal vein) as the model input function