. 2019 Apr 29;21(4):61. doi: 10.1208/s12248-019-0323-0

Table IV.

Parameter Estimates of the 4C Model for the [¹¹C]Erlotinib + Rifampicin Data Set

Subject	Arterial input function			Dual input function
Subject	k₁ (min⁻¹)	k₂ (min⁻¹)	k₃ (min⁻¹)	k₅ (min⁻¹)	k₁ (min⁻¹)	k₂ (min⁻¹)	k₃ (min⁻¹)	k₅ (min⁻¹)	β (min)
Baseline scan
p37	2.100 (11)	0.150 (14)	0.035 (10)	0.008 (4)	3.463 (12)	0.102 (18)	0.076 (12)	0.011 (2)	0.879 (59)
p38	2.339 (7)	0.072 (9)	0.057 (9)	0.009 (2)	3.579 (6)	0.083 (57)	0.724 (21)	0.009 (1)	1.755 (54)
p39	2.264 (7)	0.075 (8)	0.066 (10)	0.016 (3)	3.378 (1)	0.023 (16)	0.759 (16)	0.014 (1)	1.157 (25)
p40	1.821 (2)	0.002 (78)	0.074 (6)	0.009 (1)	5.091 (2)	0.006 (69)	1.172 (29)	0.010 (2)	0.839 (60)
p41	2.501 (6)	0.050 (18)	0.100 (7)	0.009 (1)	4.371 (3)	0.0003(21)	0.622 (18)	0.010 (1)	1.708 (90)
p42	1.211 (7)	0.001(342)	0.044 (17)	0.027 (10)	3.376 (18)	0.061(184)	0.603 (37)	0.014 (2)	1.678 (60)
Mean ± SD	2.039 ± 0.467	0.058 ± 0.056	0.063 ± 0.023	0.013 ± 0.008	3.876 ± 0.704	0.046 ± 0.042	0.659 ± 0.353	0.011 ± 0.002	1.336 ± 0.429
Second scan (after i.v. rifampicin)
p37	1.700 (4)	0.069 (7)	0.025 (7)	0.029 (7)	2.250 (26)	0.016 (61)	0.036 (26)	0.029 (23)	2.17 (106)
p38	1.062 (5)	0.035 (6)	0.029 (8)	0.007 (4)	2.752 (8)	0.043 (17)	0.046 (7)	0.008 (2)	1.626 (82)
p39	1.527 (6)	0.059 (11)	0.036 (9)	0.014 (4)	2.700 (4)	0.027 (24)	0.062 (17)	0.020 (7)	1.614 (92)
p40	1.770 (2)	0.008 (6)	0.003 (1)	0.224 (9)	4.399 (3)	0.008 (7)	0.004 (1)	0.179 (7)	1.993 (75)
p41	2.251 (5)	0.015 (35)	0.096 (7)	0.015 (2)	4.641 (4)	0.001 (27)	0.464 (20)	0.012 (1)	2.168 (93)
p42	1.135 (3)	0.008 (14)	0.014 (2)	0.180 (14)	3.452 (18)	0.150 (52)	0.408 (25)	0.021 (2)	2.167(143)
Mean ± SD	1.574 ± 0.440	0.032 ± 0.027	0.034 ± 0.033	0.078 ± 0.097	3.366 ± 0.976	0.041 ± 0.056	0.170 ± 0.208	0.045 ± 0.066	1.956 ± 0.269

For legend to this table, see Table II legend