Table II.

Mean Serum Sodium at Pre-dose and During Treatment, and Change from Pre-dose in Water-Loaded Subjects by Treatment Group

	Mean Serum Sodium (mmol/L)				Change from Pre-Dose (mmol/L)
	AV002 Nasal Spray			SC	AV002 Nasal Spray			SC
	0.5 μg (N = 12)	1.0 μg (N = 12)	2.0 μg (N = 12)	0.12 μg (N = 6)	0.5 μg (N = 12)	1.0 μg (N = 12)	2.0 μg (N = 12)	0.12 μg (N = 6)
Pre-dose	136.7	133.7	132.0	134.3	−	−	−	−
2 Hr. Post Dose	134.2	130.2	131.4	130.7	−2.5	−3.5	−0.6	−3.6
4 Hr. Post Dose	135.6	131.6	132.0	130.5	−1.1	−2.1	0	−3.8
6 Hr. Post Dose	137.5	134.5	132.0	132.3	0.8	0.8	0.8	−2.0
8 Hr. Post Dose	138.6	135.8	134.7	134.2	1.9	2.1	2.7	−0.1

Hr hour, SC subcutaneous desmopressin injection