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. 2019 Apr 29;9:6623. doi: 10.1038/s41598-019-42964-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MSC-Ex treatment attenuates AD in the Af-induced mouse model. (A) Schematic protocol for Af -induced mouse AD and s.c. injection of MSCs (2 × 10⁶ cells) or MSC-Ex (300 µg), respectively. (B) Clinical symptom scores were calculated on the last day of the experiment (day 28) based on the clinical Psoriasis Area and Severity Index. (C) TEWL in the mouse dorsal skin was measured at the end of the experiment. (D) The IgE levels in serum were measured using ELISA. Data are represented as the means ± s.d. (n ≥ 6 mice per group). *P < 0.05, **P < 0.005, ***P < 0.001.