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. 2019 Apr 29;9:6622. doi: 10.1038/s41598-019-43054-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of UM171 on NK cell production from hPSC-derived HPs. (A) Schematic diagram of protocol used for NK cell differentiation of hPSC-derived HPs. (B) Representative flow cytometry dot plots displaying NK cell differentiation. (C,D) Percentages and fold change in absolute numbers of NK cells. Bars are mean ± SEM for at least 6 independent experiments. **p < 0.01, ***p < 0.001. (E) Cytotoxicity assay against K562 targets. Representative dot plots and dose dependent cell lysis curves (mean ± SEM for n = 3) are shown. (F) Expression of perforin in unstimulated NK cells and INFγ following stimulation of NK cells with K562 or PMA.