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. 2019 Apr 29;9:6624. doi: 10.1038/s41598-019-43006-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Signature #2 correlates with reductions in OS in patients with breast cancer. The impact of Signature #2 on OS in the entire BC population (A), ER + subpopulation (B), and normal-like subclass (C) within the Curtis dataset (n = 1980)⁶ was determined. (D–G) Data from the TCGA-Cell dataset (n = 817)³⁴ was used to evaluate the impact of Signature #2 on OS (D,F) and DFS (E,G) for the entire population in the indicated follow-up period (D,E) as well as for lobular breast cancers (E,F,H) Data from the Curtis dataset (n = 1980)⁶ were analyzed for the effects of Signature #2 on OS for patients with lobular breast cancer. Statistical analysis was performed using Logrank Test. dec: deceased cases; MMS: median months survival; relap: relapse cases. For breast tumor composition in both datasets, please see Table S7.