Table 2.

Univariate and multivariate cox analysis of CYB5D2-derived Signature #2.

Clin var and siga	Univaraite			Multivariate
	HRb	95% CIc	p-value	HR	95% CI	p-value
Signature #2	1.51	1.34–1.7	8.04-e12*	1.28	1.08–1.52	0.004*
Age at diagnosis	1.04	1.03–1.04	2e-16*	1.03	1.03–1.04	2e-16*
Cellularity	1.02	0.94–1.12	0.618	0.99	0.88–1.10	0.828
Integrat Cluster d
Cluster 3	0.72	0.55–0.94	0.016*	0.95	0.68–1.34	0.779
Cluster 5	1.56	1.18–2.06	0.002*	1.65	1.17–2.31	0.004*
Neo His Ge	1.28	1.17–1.41	3.35e-7*	0.75	0.62–0.92	0.005*
N Prog indexf	1.32	1.26–1.40	2e-16*	1.399	1.23–1.59	1.78e-7*
Tumor size	1.01	1.012–1.018	2e-16*	1.001	1.004–1.013	9.51e-5*
Tumor stage	1.81	1.63–2.02	2e-16*	1.14	0.96–1.35	0.123

^aClinical variables and Signature #2.

^bhazard ratio.

^cconfidence interval.

^dintegrative cluster.

^eneoplasm histologic grade.

^fnottingham prognostic index.