Fig. 4. Effect of curcumin on the (A) mRNA and (B) protein level of apolipoprotein B (apoB) mRNA editing enzyme components in primary mouse hepatocytes.

The cells were treated with 5, 25, and 50 µM curcumin. After 48 h treatment, RNA was isolated from cells, real-time quantitative polymerase chain reaction and Western blotting was carried out to evaluate the expression levels of the RNA editing enzymes. Results were repeated twice and are displayed as mean ± standard deviation. APOBEC-1, apoB editing catalytic polypeptide-1; RBM47, RNA-binding-motif-protein-47; ACF, apobec-1 complementation factor; GRY-RBP, glycine-arginine-tyrosine-rich RNA binding protein; hnRNP, heterogenous nuclear ribonucleoprotein; CUGBP2, CUG binding protein-2; ABBP2, apobec-1 binding protein-2. ^*p < 0.05.