Fig. 6. Curcumin modulates the apolipoprotein B (apoB) mRNA editing by coordinating the expression of multiple editing components of cytidine deamination to uridine (C-to-U) editosome.

Curcumin increased the expression of the three core components APOBEC-1, RBM47, and ACF, but reduced the expression of only one auxiliary inhibitory protein GRY-RBP. APOBEC-1, apoB editing catalytic polypeptide-1; RBM47, RNA-binding-motif-protein-47; ACF, apobec-1 complementation factor; GRY-RBP, glycine-arginine-tyrosine-rich RNA binding protein; hnRNP, heterogenous nuclear ribonucleoprotein; CUGBP2, CUG binding protein-2; ABBP2, apobec-1 binding protein-2; LDLR-BD, low-density lipoprotein receptor-binding domain.