RNA-sequencing data highlighting the time-of-day-dependent transcriptome of the central circadian pacemaker in Sox2-deficient mice

. 2019 Apr 8;24:103909. doi: 10.1016/j.dib.2019.103909

Specifications table

Subject area	Biology
More specific subject area	Circadian rhythm; chronobiology
Type of data	Tables, figures and graphs
How data were acquired	RNA sequencing using Illumina HiSeq4000 platform
Data format	Raw and analyzed
Experimental factors	Organism: Mus musculus Strain background: C57BL6 x FVB x 129/SvEv Developmental stage: Adult Tissue: Suprachiasmatic nucleus Genotype: Sox2^fl/fl (control) and Vgat-cre;Sox2^fl/fl mice
Experimental features	Mice were maintained on a fixed 12-h light: 12-h dark schedule and released into constant darkness for two consecutive cycles prior to tissue harvest. RNA from the suprachiasmatic nuclei was extracted and libraries were prepared and sequenced.
Data source location	Department of Biology, University of Toronto Mississauga, Canada
Data accessibility	The RNA-seq data are publicly available at the ArrayExpress database at EMBL-EBI (https://www.ebi.ac.uk/arrayexpress) under accession number E-MTAB-7496
Related research article	A.H. Cheng, P. Bouchard-Cannon, S. Hegazi, C. Lowden, S.W. Fung, C.-K. Chiang, R.W. Ness, H.-Y.M. Cheng, SOX2-dependent transcription in clock neurons promotes the robustness of the central circadian pacemaker, Cell Rep, 26, 2019, 3191–3202, https://doi.org/10.1016/j.celrep.2019.02.068. [1]