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. 2019 Apr 29;4(2):234–247. doi: 10.1016/j.jacbts.2018.11.011

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Nuclear HMGB1 and p-ATM Expression in Failing Human Heart

(A to C) Representative images and analysis of immunostaining of high-mobility group box 1 (HMGB1) (green), phosphorylation of ataxia telangiectasia mutated (p-ATM) (red), and DAPI (blue) in normal human hearts and failing human hearts. The number of HMGB1- and p-ATM–positive cardiomyocytes (CMs) per field was counted. Scale bars = 20 μm. Results are presented as the mean ± SE. (n = 5 per group). ∗p < 0.05; ∗∗∗p < 0.001. (D to F) Negative correlation between nuclear HMGB1-positive CM and cardiomyocyte diameter (MyD), collagen volume fraction (CVF), or serum brain natriuretic peptide (BNP) levels (n = 32).