Figure 2.

SC CCF and RCR With Elamipretide Treatment

(A) Supercomplex coupling control factor (SC CCF) ratio is lower in untreated HF than NF controls. Elamipretide treatment does not alter SC CCF in (B) NF hearts but improves SC CCF in (C) HF. (D) The respiratory control ratio (RCR) trends lower in untreated NF hearts versus HF hearts. Elamipretide treatment has no effect on RCR in (E) NF hearts but increases RCR in (F) HF hearts. Untreated hearts in B, C, E and F are shown with closed circles and treated hearts with open circles. NF, n = 13; HF, n = 23. Abbreviations as in Figure 1.