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. 2019 Mar 13;4(2):161–172. doi: 10.1016/j.jacbts.2018.11.001

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Impact of GLC and GLC Receptor Antagonist on Cardiac Function and Chamber Dilation in Post-Myocardial Heart

(A) Fractional shortening and (B) left ventricular end-systolic dimension (LVESD) in MI hearts treated with PBS (Control; n = 10, blue), GLC (n = 6, purple), and GLC receptor antagonist (REMD; n = 11; red) at different time points recorded by echocardiogram. #p < 0.05 REMD versus Control; REMD versus GLC. (C) Left ventricular developed pressure (LVDP). (D) Left ventricular systolic pressure (LVSP). (E) Maximum pressure derivative (+dP/dtmax) and (F) Minimum pressure derivative (–dP/dtmin) as measured by conductance catheter. Abbreviations as in Figure 1.