Figure 4.

Radiographic Differences Between Groups

Axial T2 images (A) were assessed for radiographically apparent injuries (B), which were outlined as moderate (green) or severe (red) on a voxel-per-voxel basis. These areas of injury were corroborated by review of apparent diffusion coefficient mapping (C), which were similarly outlined (D). (E) Areas of injury were rendered in 3 dimensions and overlaid onto an image of the brain to provide a visual image of the differences in the volume of cranial injury. Data were based on brain MRI of 8 swine in the hydrogen-treated group and 6 in the control group (2 swine allocated to the control group died from refractory seizures and could not survive to day 3). (F) H₂-treated animals exhibited a significantly lower volume of injury than did control animals (Student t-test: p = 0.0463). The line represents median, boxes are interquartile ranges, and error bars are minimum and maximum values.