Table 3.

Association of VKORC1 and CYP2C9 SNPs with variability on warfarin required doses.

Gene	SNP ID	Genotype	Initiation dose	P-value *	Maintenance dose	P-value*
VKORC1	rs10871454	CC	51.35 [15.55]	<0.0001	53.02 [18.02]	<0.0001
		CT	35.33 [14.42]		39.48 [17.06]
		TT	26.56 [10.89]		27.41 [10.33]
	rs8050894	CC	51.84 [15.32]	<0.0001	53.06 [18.39]	<0.0001
		CG	35.76 [14.81		39.96 [17.33]
		GG	26.73 [10.58]		27.80 [10.22]
	rs9934438	CC	51.35 [15.55]	<0.0001	53.02 [18.02]	<0.0001
		CT	35.56 [14.28]		39.47 [16.83]
		TT	25.72 [10.46]		26.82 [10.19]
	rs17708472	CC	33.67 [15.68]	0.012	36.37 [18.13]	0.003
		CT	41.64 [15.53]		44.20 [15.04]
		TT	57.80 [8.08]		59.63 [9.79]
CYP2C9	rs1799853	CC	37.22 [16.37]	0.154	40.00 [18.30]	0.189
		CT	32.54 [15.11]		34.68 [16.23]
		TT	21.25 [0.354]		25.00 [0.00]
	rs4086116	CC	40.61 [16.81]	0.0002	43.86 [19.10]	0.0002
		CT	30.90 [13.38]		32.55 [14.39]
		TT	25.23 [11.56]		28.57 [8.76]
	rs1057910	AA	39.06 [16.32]	<0.0001	41.75 [18.48]	<0.0001
		AC	24.95 [9.34]		27.43 [9.29]

^*One-way ANOVA test with P-value < 0.05 is considered significant, Mean Standard deviation in square brackets.