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. 2019 Apr 20;24:101206. doi: 10.1016/j.redox.2019.101206

Figure 1.

Figure 1

Novel derivatives of vitamin D3 and lumisterol reduce oxidant formation in UVB-irradiated keratinocytes. Keratinocytes were pretreated with the indicated vitamin D3 and lumisterol hydroxy-derivatives for 24 h prior to UV irradiation (50 mJ/cm2). The irradiated cells were further incubated for an additional 4 h with the hydroxy-derivatives or ethanol vehicle, while non-irradiated cells were treated with the ethanol vehicle (comparison presented as insert, top right). Oxidant formation was examined using the DCFDA reagent at 4 h post UVB irradiation. Data are presented as the percentage of the control (mean ± SD). The statistical significance of differences was evaluated by one-way ANOVA, * P < 0.05, ** P < 0.01, *** P < 0.001 for all conditions.