Table 1.
Composition of the prepared formulations of sublingual tablets containing ATOR-TMZ combination.
| Ingredients | Formula composition (mg)a |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | |
| Solubilized ATORb | 50.8 | 50.8 | 50.8 | 50.8 | 50.8 | 50.8 | 50.8 | 50.8 | 50.8 | 50.8 | 50.8 | 10 |
| TMZ | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 |
| Mg stearate | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| Cherry flavor | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
| Saccharin sodium | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 |
| Ac-Di-Sol | – | 10 | 20 | – | – | 10 | 12 | 12 | 12 | 24 | – | – |
| Explotab | – | – | – | 10 | 20 | 10 | 12 | 12 | – | – | 24 | – |
| Crospovidone | – | – | – | – | – | – | – | – | 12 | – | – | 24 |
| Soluplus | 145.2 | 135.2 | 125.2 | 135.2 | 125.2 | – | – | – | – | – | – | – |
| Anhydrous lactose | – | – | – | – | – | 125.2 | 121.2 | – | – | – | – | |
| Avicel pH 101 | – | – | – | – | – | – | – | 121.2 | 121.2 | 121.2 | 121.2 | 121.2 |
a
Total tablet weight was 250 mg.
b
Solubilized ATOR is ATOR-SBE- β-CD loaded mixture (1:2 M ratio).