Table 2. Univariate and multivariate Cox regression of prognostic factors in osteosarcoma patients.

Parameter	Univariate analysis			Multivariate analysis
	HR	95% CI	P	HR	95% CI	P
Age (y)
(≤18 vs >18)	0.698	0.441–1.104	0.124
Gender
(Female vs ≥male)	1.351	0.832–2.195	0.224
Enneking stage
(I–II A vs II B–III)	2.949	1.723–5.045	<0.001	1.134	0.486–2.646	0.770
Tumor size
(≤8 vs >8 cm or discontinuous tumors)	1.808	1.140–2.868	0.012	1.227	0.744–2.023	0.423
Distant metastasis
(Absence vs presence)	6.007	3.334–10.823	<0.001	3.592	1.906–6.767	<0.001
Histological grade
(G1–G2 vs G3–G4)	2.578	1.572–4.227	<0.001	1.589	0.772–3.272	0.209
Tumor site
(Femur/tibia vs other)	1.586	0.909–2.766	0.104
LOXL1-AS1 expression
(Low vs high)	3.374	2.071–5.496	<0.001	1.985	1.096–3.597	0.024

Abbreviation: HR, hazard ratio.