Figure 5.

TUNEL staining (400×) shows that SPRK1 gene silencing reduces VSMC apoptosis in rats with IA. Panel A and B, TUNEL staining demonstrates apoptotic VSMCs in the intracranial artery. The si‐SRPK1 group had significantly reduced apoptosis rate, while the IGF‐1 group had significantly increased apoptosis rate. *P < 0.05 vs the sham group; #P < 0.05 vs the IA group; &P < 0.05 vs the si‐SRPK1 + IGF‐1 group; $P < 0.05 vs the SRPK1 + LY294002 group. VSMCs, vascular smooth muscle cells; TUNEL, Terminal deoxynucleotidyl transferase (TdT)‐mediated dUTPbiotin nick end labeling; IA, intracranial aneurysm; SRPK1, SR protein‐specific kinases