Figure 6.

Microscopic examination and CCK‐8 assay show that SRPK1 gene silencing promotes VSMCs proliferation in rats with IA. Panel A, VSMCs were observed under a light microscope and a fluorescence confocal microscope (400×). VSMCs were identified by their red fluorescence appearance and a positive rate >95%; Panel B, cell viability detected by CCK‐8 assay was increased in the si‐SPRK1 group. *P < 0.05 vs the sham group; #P < 0.05 vs the si‐SRPK1 + IGF‐1 group; $P < 0.05 vs the SRPK1 + LY294002 group. VSMCs, vascular smooth muscle cells; CCK8, Cell counting kit‐8; IA, intracranial aneurysm; SRPK1, SR protein‐specific kinases