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. 2019 Jan 24;25(5):575–590. doi: 10.1111/cns.13086

Figure 4.

Figure 4

Effects of BAI on the activation of NLRP3 inflammasomes and TLR4/NF‐κB signaling pathway in hippocampal homogenates of APP/PS1 mice. (A) Representative immunoblots probed with antibodies against NLRP3, Cleaved‐CASP1, IL‐1β, IL‐18, and β‐actin. (B) Quantification of the levels of NLRP3, Cleaved‐CASP1, IL‐1β, and IL‐18 normalized to β‐actin. (C) Representative immunoblots probed with antibodies against TLR4, p‐NF‐κB p65, NF‐κB p65, p‐IκBα, IκBα, and β‐actin. (D) Quantification of the levels of TLR4, p‐NF‐κB p65, NF‐κB p65, p‐IκBα, and IκBα normalized to β‐actin. All data are presented as mean ± SD (n = 4). *P < 0.05, **P < 0.01, compared with wild‐type (WT) group; #P < 0.05, ##P < 0.01, compared with APP/PS1 group