Table 2.

Number, percentage of variance explained and accuracy of genetic predictors from SNPs found associated (P < 10⁻⁸) with height or BMI in a random sample of 250 000 unrelated participants of the UKB

	Height		BMI
	Random samplefrom UKB	Wood et al. (5)	Random samplefrom UKB	Locke et al. (6)
Number of near-independent genome-wide significant SNPs (GWS; COJO P < 10−8)	850	594	160	82
Variance explained by GWS	14.0%	12.8%	2.3%	1.8%
Prediction accuracy (r2)	14.0%	10.9%	2.5%	1.8%

For comparison, similar statistics are reported from GWAS hits identified in (5) and (6). Prediction accuracy (squared correlation r², between genetic predictors and traits) and variance explained (estimated using GCTA software) is assessed in 8552 unrelated participants of the HRS.