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. 2019 Apr 5;17(6):4693–4702. doi: 10.3892/etm.2019.7470

Figure 2.

Figure 2.

Overexpression of miR-153 suppresses the malignant phenotype in SK-BR-3 and BT-549 cells. miR-153 mimic and scramble miR mimic were transiently transfected into SK-BR-3 and BT-549 cells, respectively. (A) The expression level of miR-153 was detected by reverse transcription-quantitative polymerase chain reaction. The effect of miR-153 overexpression on (B) SK-BR-3 and (C) BT-549 cell growth was analyzed by Cell Counting kit-8 assay. The effect of miR-153 overexpression on (D) SK-BR-3 and (E) BT-549 cell migration was analyzed using the wound healing assay (magnification, ×40). (F) The effect of miR-153 overexpression on SK-BR-3 and BT-549 cell invasion was analyzed using the transwell invasion assay (magnification, ×200). The protein expression levels of E-cadherin, N-cadherin and vimentin in (G) SK-BR-3 and (H) BT-549 cells were determined by western blotting. **P<0.01 vs. miR-NC. SK-BR-3 and BT-549, human breast cancer cell lines; miR, microRNA; miR-NC, breast cancer cell lines SK-BR-3 and BT-549 transfected with scramble miR; miR-153, breast cancer cell lines SK-BR-3 and BT-549 transfected with miR-153 mimic.