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. 2019 Apr 17;41(6):3270–3280. doi: 10.3892/or.2019.7123

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Copyright: © Ban et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Knockdown of LRG-1 prevents the EMT process in the thyroid cancer HTC/C3 and SW579 cell lines. (A) The mRNA and (B) protein levels of EMT-associated markers (E-cadherin, N-cadherin and vimentin) in thyroid cancer cells transfected with shLRG-1 or control scramble shRNA were measured by qPCR and western blot assays. (C) Expression levels of SNAIL1, SNAIL2, ZEB1 and ZEB2 in LRG-1-knockdown and control thyroid cancer cells. Data are presented as the mean ± SD (three independent experiments). *P<0.05; **P<0.01; ***P<0.001 vs. control (shCtrl). LRG-1, leucine-rich-alpha-2-glycoprotein 1; EMT, epithelial-mesenchymal transition.