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. 2019 Apr 12;41(6):3189–3200. doi: 10.3892/or.2019.7113

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Copyright: © Cheng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — ARPC2 is upregulated in breast cancer cell lines and specimens from patients with breast cancer. (A) The level of ARPC2 mRNA was higher in breast cancer cell lines than MCF-10A non-malignant cells through qRT-PCR. **P<0.01. (B) ARPC2 protein expression in breast cancer cell lines was higher than in MCF-10A non-malignant cells. (C) Relative ARPC2 expression in breast cancer and normal breast tissues analyzed though IHC. Breast cancer cells feature strong-moderate cytoplasmic staining; normal tissues exhibit weak staining. (D) Kaplan-Meier overall survival curves generated in accordance to the ARPC2 protein levels of patients with breast cancer (low vs. high); ARPC2 was associated with worse overall survival. (E) Ratio of ARPC2 mRNA in different BrCa types was analyzed using TCGA database. ARPC2, actin-related protein 2/3 complex; TCGA, The Cancer Genome Atlas. The dots mean extreme outlier.