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. 2019 Apr 15;41(6):3201–3208. doi: 10.3892/or.2019.7117

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Copyright: © Wu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Signature genes and signaling pathways responsible for the high cancer stemness of ESCC. (A) Venny analysis of upregulated genes in the cancer stemness of ESC02 and ESC03. A total of 338 upregulated genes were identified. Among these, a total of 35 significantly upregulated genes were listed (P<0.01). Previously reported stemness-associated genes were marked in red; the references were given in Table SII. (B) Database for Annotation, Visualization and Integrated Discovery-Kyoto Encyclopedia of Genes and Genomes analysis of upregulated genes in ESCC. The signaling pathways of DNA replication, Fanconi anemia pathway, RNA transport and nucleotide excision repair were significantly enriched in the cancer stemness of ESCC (P<0.05). ESCC, esophageal squamous cell carcinoma; SI, stemness index; ANGEL2, angel homolog 2; APPBP2, amyloid β precursor protein binding protein 2; BRD8, bromodomain containing 8; CDCA7, cell division cycle associated 7; CEP89, centrosomal protein 89; CUL7, cullin 7; DDX11, DEAD/H-Box Helicase 11; ECHDC2, enoyl-CoA hydratase domain containing 2; FAM111A, family with sequence similarity 111 member A; FAM13A, family with sequence similarity 13 member A; FBXW2, F-Box and WD repeat domain containing 2; FGFR10P, FGFR1 oncogene partner; FN3KRP, fructosamine 3 kinase related protein; GAR1, GAR1 ribonucleoprotein; GMCL1, germ cell-less, spermatogenesis associated 1; GNPDA1, glucosamine-6-phosphate deaminase 1; INTS4, integrator complex subunit 4; KIF11, kinesin family member 11; MGAt1, mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase; MPP1, membrane palmitoylated protein 1; NBPF1, NBPF member 1; OGFOD3, 2-oxoglutarate and iron dependent oxygenase domain containing 3; PAK1IP1, p21-activated protein kinase-interacting protein 1; PARP4, poly(ADP-ribose) polymerase family member 4; PRIM2, DNA primase subunit 2; RAD17, RAD17 checkpoint clamp loader component; SNIP1, Smad nuclear interacting protein 1; TPRA1, transmembrane protein adipocyte associated 1; TRAF5, TNF receptor associated factor 5; USP11, ubiquitin specific peptidase 11; WDR92, WD repeat domain 92; WLS, Wntless Wnt ligand secretion mediator; ZADH2, zinc binding alcohol dehydrogenase domain containing 2; ZMYM2, zinc finger MYM-type containing 2; ZNF761, zinc finger protein 761.