Figure 3.

Effect of yeast and/or paclitaxel on the percentage of cell proliferation, DNA damage and apoptosis in tumor tissues of the different groups. Data are expressed as mean ± SE (5 mice/group). ^CP<0.01, significantly different from the EAC group. ^dP<0.05 and ^DP<0.01, significantly different from the yeast-treated EAC group. ^EP<0.01, significantly different from the paclitaxel-H-treated EAC group. ^FP<0.01, significantly different from the paclitaxel-- treated EAC group. ^GP<0.01, significantly different from the yeast + paclitaxel-H-treated EAC group. EAC, Ehrlich ascites carcinoma. Groups: EAC, mice bearing tumors receiving intratumoral (i.t.) injections of PBS; Yeast, mice bearing tumors receiving i.t. injections of yeast (1×10⁷ cells/ml); paclitaxel-H, mice bearing tumors receiving paclitaxel at a high dose (10 mg/kg); paclitaxel-L, mice bearing tumors receiving paclitaxel at a low dose (2 mg/kg); Yeast + Paclitaxel-H, mice bearing tumors receiving yeast plus paclitaxel-H; Yeast + Paclitaxel-L, mice bearing tumors receiving yeast plus paclitaxel-L.