Table 1.
Genome-wide association studies of hypertension and several other cardiovascular diseases and abnormalities
| Study [Ref.], year | Initial sample size, n | Replication sample size, n | Major ethnic group | Top locus |
|---|---|---|---|---|
| Blood pressure | ||||
| Levyet al.[8], 2009 | 29,136 | 34,433 | European | SH2B3 |
| Newton-Chehet al.[7], 2009 | 34,433 | 113,236 | European | CNNM2 |
| Kato et al. [12], 2011 | 19,608 | 30,765 | Asian | HECTD4 |
| Wainet al. [10], 2011 | 74,064 | 48,607 | European | ATXN2 |
| Ehret et al. [9], 2011 | 69,395 | 133,361 | European | CSK |
| Warren et al. [11], 2017 | 140,886 | 190,318 | European | JAG1 |
| Coronary artery disease | ||||
| Samani et al. [17], 2007 | 4,864 | 2,519 | European | CDKN2B-AS1 - DMRTA1 |
| Helgadottir et al. [42], 2007 | 8,335 | 9,289 | European | CDKN2B-AS1 - DMRTA1 |
| Trégouët et al. [43], 2009 | 4,864 | 14,398 | European | LPA |
| Erdmannet al. [44], 2009 | 2,520 | 38,253 | European | MRAS |
| Reillyet al. [45], 2011 | 2,723 | 17,053 | European | ADAMTS7 |
| C4DGeneticsConsortium et al. [46], 2011 | 30,482 | 40,593 | European, Asian | PHACTR1 |
| Schunkert et al. [47], 2011 | 86,995 | 56,682 | European | CDKN2B-AS1 |
| Lu et al. [48], 2012 | 6,534 | 26,932 | Asian | CDKN2B-AS1 |
| Nikpay et al. [19], 2015 | 187,599 | None | European, Asian | CDKN2B-AS1 |
| Nelson et al. [20], 2017 | 63,731 | 276,868 | European, | CDKN2B-AS1 |
| Congestive heart failure | ||||
| Smith et al. [49], 2010 | 23,821 | None | European, African | LRIG3 |
| Dilated cardiomyopathy | ||||
| Villard et al. [50], 2011 | 2,287 | 2,467 | European | TSPB7 |
| Atrial fibrillation | ||||
| Gudbjartsson et al. [51], 2009 | 36,137 | 8,855 | European | ZFHX3 |
| Ellinor et al. [52], 2010 | 14,179 | 4,771 | European | KCNN3 |
| Ellinor et al. [53], 2012 | 59,133 | 5,381 | European | PITX2 - MIR297 |
| Lowet al. [54], 2017 | 36,792 | 257,896 | Asian, European | PITX2 - MIR297 |
| Electrocardiographic abnormalities in the PR interval | ||||
| Pfeufer et al. [55], 2010 | 28,517 | None | European | SCN10A |
| Chambers et al. [56], 2010 | 6,543 | 6,243 | Asian | SCN10A |
| QRS duration | ||||
| Sotoodehnia et al. [57], 2010 | 40,407 | 7,170 | European | SCN10A |
| QT interval | ||||
| Arking et al. [58], 2006 | 200 | 4,451 | European | NOS1AP, LOC105371475 |
| Newton-Cheh et al. [59], 2009 | 13,685 | 15,854 | European | LOC107985450 - NOS1AP |
| Arking et al. [60], 2014 | 70,389 | 33,316 | European | LOC107985450 – NOS1AP |
| Heart rate | ||||
| den Hoed et al. [61], 2013 | 92,355 | 88,823 | European | MYH6 |
| Nolte et al. [62], 2017 | 26,523 | 38,558 | European, Hispanic, African American | NDUFA11 |
| Dyslipidemia | ||||
| Saxena et al. [63], 2007 | 5,217 | None | European | APOC1 – APOC1P1 |
| Kooner et al. [64], 2008 | 2,011 | 10,536 | European, Mexican, Asian | MLXIPL |
| Kathiresan et al. [35], 2008 | 19,840 | 20,623 | European | HERPUD1 – CETP |
| Sandhu et al. [65], 2008 | 11,685 | 4,979 | European | CELSR2 - PSRC1 |
| Teslovich et al. [16], 2010 | 96,598 | None | European | ZPR1 |
| Kim et al. [66], 2011 | 12,545 | 30,395 | Asian | ZPR1 |
| Willer et al. [67], 2013 | 94,595 | 93,982 | European | LDLR |
| Ko et al. [68], 2014 | 3,323 | 6,017 | Mexican | ZPR1 |
| Surakka et al. [69], 2015 | 62,166 | None | European | APOE |