Table 3.

Significant loci for coronary artery disease reported by genome-wide association studies in Europeans (a) and Asians (b)

Chr	Strongest SNP	Position	EA	EAF	OR or BETA	p value	n	Closest gene	Ref.
a 1	Europeans rs11206510	55030366	T	0.85	1.08	2.34E–08	188,372	PCSK9	[19]
1	rs17114036	56497149	A	0.91	1.17	3.81E–19	133,226	PPAP2B	[47]
1	rs629301	109275684	NA	NA	NA	1.00E–49	NA	CELSR2	[78]
1	rs11810571	151789832	G	0.79	1.06	4.34E–08	345,035	TDRKH	[20]
1	rs6689306	154423470	A	0.44	1.05	1.50E–09	NA	IL6R	[20]
2	rs16986953	19742712	A	0.07	1.11	4.80E–10	NA	AK097927	[20]
2	rs7568458	85561052	A	0.45	1.06	2.40E–13	NA	VAMP5, VAMP8, GGCX	[20]
2	rs17678683	144528992	G	0.09	1.10	3.00E–09	179,585	ZEB2, ACO74093.1	[19]
2	rs1250229	215439661	T	0.26	1.07	2.88E–13	270,189	FN1	[20]
3	rs7623687	49411133	A	0.86	1.08	3.54E–10	333,836	RHOA	[20]
3	rs142695226	124756354	G	0.14	1.07	1.58E–09	345,188	UMPS, ITGB5	[20]
3	rs9818870	138403280	T	0.15	1.15	7.44E–13	40,773	MRAS	[44]
3	rs12493885	154122077	C	0.87	1.07	3.23E–08	251,805	ARHGEF26	[20]
4	rs17087335	56972417	T	0.21	1.06	4.60E–08	NA	NOA1, REST	[19]
4	rs10857147	80259918	T	0.27	1.05	5.81E–09	345,133	PRDM8, FGF5	[20]
4	rs7678555	119988346	C	0.28	1.05	1.35E–08	345,126	PDE5A, MAD2L1	[20]
4	rs6841581	147480038	A	0.15	1.07	4.60E–10	NA	EDNAA	[20]
6	rs6909752	22612400	A	0.33	1.05	2.26E–09	343,171	HDGFL1	[20]
6	rs17609940	35067023	G	0.75	1.07	1.36E–08	137,412	ANKS1A	[47]
6	rs56336142	39166323	T	0.81	1.07	1.85E–08	188,349	KCNK5	[19]
6	rs12190287	133893387	C	0.62	1.08	1.70E–12	130,888	TCF21	[47]
6	rs10455872	160589086	G	0.07	1.31	1.70E–49	NA	LPA	[20]
6	rs4252185	160702419	C	0.06	1.34	1.64E–32	NA	PLG	[19]
7	rs2107595	19009765	A	0.18	1.08	3.40E–13	NA	HDAC9	[20]
7	rs11556924	130023656	C	0.62	1.09	9.18E–18	134,200	ZC3HC1	[47]
7	rs3918226	150993088	T	0.07	1.13	1.60E–12	NA	NOS3	[20]
8	rs2954029	125478730	A	0.54	1.06	5.20E–13	NA	TRIB1	[20]
9	rs579459	133278724	C	0.21	1.10	4.08E–14	123,978	ABO	[47]
10	rs2505083	30046193	C	0.39	1.06	6.85E–09	169,421	KIAA1462	[19]
10	rs501120	44258419	T	0.87	1.33	9.46E–08	7,181	CXCL12	[17]
10	rs2246942	89245129	G	0.35	1.08	3.50E–16	NA	LIPA	[20]
10	rs12413409	102959339	G	0.89	1.12	1.03E–09	129,741	NT5C2, CNNM2, CYP17A1	[47]
11	rs10840293	9729649	A	0.55	1.05		NA	SWAP70	[20]
11	rs3993105	13281524	T	0.68	1.05	4.88E–08	340,699	ARNTL	[20]
11	rs974819	103789839	T	0.32	1.07	2.41E–09	64,881	PDGFD	[46]
11	rs964184	116778201	NA	NA	NA	2.00E–108	NA	ZPR1	[78]
12	rs3184504	111446804	T	0.42	1.07	1.03E–09	NA	SH2B3	[19]
12	rs11830157	117827636	G	0.36	1.12	2.12E–09	NA	KSR2	[19]
12	rs2244608	120979185	G	0.35	1.05	7.90E–10	345,106	HFN1A	[20]
13	rs1924981	28448508	T	0.33	1.05	1.90E–07	NA	FLT1	[20]
14	rs2895811	99667605	C	0.43	1.07	1.14E–09	114,238	HHIPL1	[47]
15	rs56062135	67163292	C	0.79	1.07	4.52E–09	184,037	SMAD3	[19]
15	rs7164479	78830712	T	0.58	1.07	6.40E–18	NA	ADAMTS7	[20]
15	rs8042271	89030987	G	0.90	1.10	3.68E–08	162,206	MFGE8, ABHD2	[19]
15	rs17514846	90873320	A	0.44	1.05	3.10E–07	NA	FURIN, FES	[19]
16	rs7500448	83012185	A	0.77	1.06	4.90E–10	337,399	CDH13	[20]
17	rs216172	2223210	C	0.37	1.07	1.15E–09	111,538	SMG6, SRR	[47]
17	rs46522	48911235	T	0.53	1.06	1.81E–08	137,633	UBE2Z	[47]
17	rs7212798	60936127	C	0.15	1.08	1.88E–08	188,377	BCAS3	[19]
18	rs8082812	8522684	NA	NA	NA	5.00E–67	NA	THEM1S3P - AKR1B1P6	[78]
18	rs663129	60171168	A	0.26	1.06	3.20E–08	NA	PMA1P1, MC4R	[19]
19	rs6511720	11091630	G	0.88	1.14	7.90E–22	NA	LDLR	[20]
19	rs12976411	32391114	A	0.09	1.49	1.18E–14	NA	ZNF507, LOC400684	[19]
19	rs8108632	41348629	T	0.48	1.05	4.13E–08	345,058	TGFB1	[20]
19	rs4420638	44919689	NA	NA	NA	1.00E–22	NA	APOC1 – APOC1P1	[78]
19	rs1964272	45687010	G	0.52	1.05	2.52E–08	343,548	SNAPD2	[20]
21	rs28451064	34221526	A	0.12	1.14	2.60E–23	NA	KCNE2	[20]
21	rs460976	41463567	NA	NA	NA	1.00E–08	NA	MX1 - TMPRSS2	[78]
22	rs180803	24262890	G	0.97	1.20	1.64E–10	174,076	POM121L9P, ADORA2A	[19]
bAsians
2	rs2123536	19745816	T	0.39	1.12	6.83E–11	33,466	TTC32, WDR35	[48]
4	rs1842896	155590307	T	0.76	1.14	1.26E–11	33,466	GUCY1A3	[48]
6	rs9349379	12903725	G	0.349	1.34	8.02E–10	4,496	PHACTR1	[79]
6	rs9268402	32373576	G	0.59	1.16	2.77E–15	33,466	BTNL2, C6orf10	[48]
6	rs12524865	133875536	C	0.61	1.11	1.87E–07	24,724	TCF21	[48]
9	rs10738607	22088095	G	0.64	0.78	2.37E–08	1,237	CDKN2A, CDKN2B	[80]
12	rs7136259	89687411	T	0.39	1.11	5.68E–10	33,466	ATP2B1	[48]
12	rs3782889	110912851	C	0.21	1.26	3.95E–14	13,742	MYL2	[81]
12	rs671	111803962	A	0.23	1.43	1.6E–34	12,041	ALDH2	[82]
12	rs11066280	112379979	A	0.17	1.19	1.69E–11	24,741	C12orf51	[48]

Chr, chromosome; EA, effect allele; EAF, effect allele frequency; NA, not available.